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Expertise in Preclinical

Excellence is a constant

We are driven by a relentless pursuit of excellence in Preclinical Science. As a veterinary-led laboratory, our team of world-class experts specializes in rigorous preclinical study planning, conducting interventional and surgical sophisticated procedures in large models in our state-of-the-art facilities with advanced imaging capabilities, and delivering pristine data collection. In addition to our renowned expertise in structural heart and cardiovascular devices, our expertise extends to a wide range of non-cardiovascular technologies. With comprehensive analysis and detailed study reports, we ensure your innovation’s development is supported from the earliest proof of concept to GLP regulatory studies.

We understand the significance of results, schedule, and cost in the value equation. Committed to delivering outstanding outcomes within budget and on time, we prioritize your success. Trust Veranex to elevate your innovations through our unwavering commitment to excellence, expertise, and exceptional value

Unmatched Expertise

As a global frontrunner in GLP-compliant cardiovascular preclinical studies, our expertise is unrivaled. With a legacy spanning 25 years, we are proud to have birthed the TAVI (Transcatheter Aortic Valve Implantation) and TMVR (Transcatheter Mitral Valve Repair) procedures in our state-of-the-art laboratory. Over the years, we have successfully performed a staggering 2500 TAVI and 1400 TMVR procedures, solidifying our position as a leader in the field.

Our extensive portfolio showcases our involvement with virtually all TAVI valves and TMVR technologies introduced to the market by major MedTech players. Our studies encompass a wide range of approaches, including both catheter-based and open-surgical methods. To facilitate these procedures with precision and efficiency, we have invested in cutting-edge facilities and equipment. Our resources include hybrid operating rooms, endoscopy and videoscopy towers, advanced CT scanning, intracardiac echocardiography imaging, and comprehensive cardiopulmonary bypass capabilities.

With our proven track record and comprehensive facilities, we stand ready to collaborate and contribute to your success.

Driving Innovation in Non-Cardiovascular Therapeutic Areas

Our expertise extends well beyond cardiovascular and structural heart. With a remarkable track record spanning diverse therapeutic areas, we have amassed significant experience in vascular intervention, neurostimulation, renal denervation, gastroenterology, robotic systems, drug delivery, ophthalmology, woman’s health technologies. Our comprehensive Preclinical Science approach in these fields has been instrumental in driving advancements and optimizing therapeutic approaches.

We have deep experience In the Vascular arena, working with Coronary, Peripheral, Carotid and Neurovascular technologies at human scale in normal as well as in pathologic models. Neuro technologies that Veranex has experience working with technologies include vagus nerve stimulation, renal denervation, embolization coils, thrombus removal devices, cortical stimulation/recording, and ultrasound-related therapies. We have also been at the forefront of gastroenterology and urology technologies, facilitating the development of innovative treatment methods. Moreover, our proficiency in surgical robotic systems and drug delivery technologies has paved the way for precise surgical procedures and improved therapeutic outcomes.

With our proven track record, deep industry knowledge, and commitment to GLP-compliant practices and ethics, we are dedicated to advancing medical innovation and driving success in critical spaces.

Key Figures

Patients treated to date with medical devices validated

Procedures per year

Implantations per year

TAVI to date

TMVR to date

TTVR to date

In addition to conducting scientific and medical device projects for human research, we have also been performing clinical veterinary cardiovascular surgery and interventional cardiology for more than 20 years.

This is the result of a long-standing partnership between Veranex and Pr Valérie Chetboul with the Cardiology Unit of the Maisons-Alfort Veterinary School near Paris.

Ever since, we operate on veterinary patients with cardiovascular conditions, place pacemakers for conduction tissue abnormalities and implant surgical or trans-catheter valves for structural heart disease, etc. In a nutshell, we leverage the technical platform and know-how of Veranex to treat cats and dogs – and the occasional exotic animal – with spontaneous heart disease.

Some of these achievements were published in peer-reviewed scientific journals and are accessible here…

Lavennes M, Chetboul V, Passavin P, Gouni V, Damoiseaux C, Poissonnier C, Carazo Arias LE, Alvarado MP, Morlet A, Chevènement O, Behr L, Borenstein N. Successful transcatheter retrieval of embolized Amplatz Canine Duct Occluders in two dogs. J Vet Cardiol. 2018 Dec;20(6):451-457.

Chetboul V, Damoiseaux C, Behr L, Morlet A, Moise NS, Gouni V, Lavennes M, Pouchelon JL, Laborde F, Borenstein NIntracardiac echocardiography: use during transcatheter device closure of a patent ductus arteriosus in a dog. J Vet Cardiol. 2017 Jun;19(3):293-298.

Borenstein N, Gouni V, Behr L, Trehiou-Sechi E, Petit A, Misbach C, Raillard M, Retortillo JL, Pouchelon JL, Pierrel A, Laborde F, Chetboul V. Surgical Treatment of Cor Triatriatum Sinister in a Cat Under Cardiopulmonary Bypass. Vet Surg. 2015 Nov;44(8):964-9. doi: 10.1111/vsu.12403. Epub 2015 Sep 28. Erratum in: Vet Surg. 2016 Apr;45(3):406.

Trehiou-Sechi E, Behr L, Chetboul V, Pouchelon JL, Castaignet M, Gouni V, Misbach C, Petit AM, Borenstein N. Echoguided closed commissurotomy for mitral valve stenosis in a dog. J Vet Cardiol. 2011 Sep;13(3):219-25.

de La Villeon G, Louvet A, Behr L, Borenstein N. Transcatheter glue arterialembolization of a mass in the hind limb of a dog. Can Vet J. 2011 Mar;52(3):289-94.

Chai N, Behr L, Chetboul V, Pouchelon JL, Wedlarski R, Tréhiou-Sechi E, Gouni V, Misbach C, Petit AM, Bourgeois A, Hazan T, Borenstein N. Successful treatment of a congenital pulmonic valvular stenosis in a snow leopard (Uncia uncia) by percutaneous balloon valvuloplasty. J Zoo Wildl Med. 2010 Dec;41(4):735-8.

Behr L, Chetboul V, Sampedrano CC, Vassiliki G, Pouchelon JL, Laborde F, Borenstein N. Beating heart mitral valve replacement with a bovine pericardial bioprosthesis for treatment of mitral valve dysplasia in a Bull Terrier. Vet Surg. 2007 Apr;36(3):190-8.

Borenstein N, Behr L, Chetboul V, Tessier D, Nicole A, Jacquet J, Carlos C, Retortillo J, Fayolle P, Pouchelon JL, Daniel P, Laborde F. Minimally invasive patent ductus arteriosus occlusion in 5 dogs. Vet Surg. 2004Jul-Aug;33(4):309-13. a

Borenstein N, Daniel P, Behr L, Pouchelon JL, Carbognani D, Pierrel A, Macabet V, Lacheze A, Jamin G, Carlos C, Chetboul V, Laborde F. Successful surgical treatment of mitral valve stenosis in a dog. Vet Surg. 2004 Mar-Apr;33(2):138-45.

François L, Chetboul V, Nicolle A, Carlos C, Borenstein N, Pouchelon JL. [Pacemaker implantation in dogs: results of the last 30 years]. Schweiz Arch Tierheilkd. 2004 Jul;146(7):335-44. French.

Nicolle A, Borenstein N, Tessier Vetzel D, Rouby M, Behr L, Pouchelon JL, Chetboul V. [Exploration of a third-degree atrioventricular block by standard echocardiography, tissue Doppler imaging, and treatment with a cardiac pacemaker in a German wire-haired pointer]. Schweiz Arch Tierheilkd. 2004 Feb;146(2):81-7.

“We are not a veterinary clinic and our primary mission is indeed to validate medical devices and novel therapeutic strategies in clinically relevant large animal preclinical models. However, it is important to us to dedicate time and resources to restoring health to pets and other animals with complex conditions. After nearly 20 years of a close and fruitful collaboration between the Veterinary School of Maisons-Alfort near Paris and Veranex, we regularly perform surgical or percutaneous patent ductus arteriosus closure, balloon dilatation of pulmonic stenosis, pacemaker implantation, and valvular replacement under cardiopulmonary bypass. We have the technical platform, the know-how and the wish to apply those techniques to veterinary patients. There are only a handful of veterinary teams worldwide that perform such interventions. It is for us a meaningful way to give back to animals for what they have given to help advance human health over the years.”

Dr Nicolas Borenstein, DVM, PhD