You be the Pathologist!

What intervention caused the lesions shown in this ovine artery?

Answer:

Application of heat generated the collateral damage observable in this artery!

Necrosis (arrowheads) is observed throughout the media (Me) of this artery. Hyalinization of the collagen (arrows) is noted in the adventitia (Ad) due to collagen denaturation. Necrosis with mineralization (star) is also observed in the adipose tissue. These types of lesions are related to thermal damage.

Safety evaluation is critical in the assessment of local reactions to treatment interventions as well as potential collateral damage. Histopathology evaluation by medical device pathologists is the gold standard for such assessment.

1: HE&S, original magnification: x20, scale bar: 50 µm.
2: Movat Pentachrome, original magnification: x20, scale bar: 50 µm.
In: Intima. Me: Media. Ad: Adventitia. Arrowhead: Necrosis of the media. Arrow: Hyalinization of collagen. Star: Cytosteatonecrosis.

This histopathology image is one example from the comprehensive suite of Pathology Services offered by Veranex Preclinical Services’ in-house team of Veterinary Pathologists.

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